A recent study suggests that individuals who discontinue popular GLP-1 drugs like Mounjaro or Wegovy can put back on shed pounds much more quickly than those who stop traditional diet and exercise plans.
Published data in a major health publication shows that while obese individuals often shed a large proportion of their total mass while on the medication, the mass returns at an estimated rate of 0.8 kg per month upon discontinuation.
"Users buying such drugs must be aware of the potential of quick rebound weight gain when the therapy concludes," warns expert Dr. Susan Jebb.
That rate of recovery means a reversion to pre-treatment mass within about a year and a half.
Comparing Therapies
The analysis, which looked at dozens of studies involving over 9,000 of participants, compared the results of these new drugs with older methods.
Scientists point out that individuals who lose weight through lifestyle changes alone typically see a less rapid weight regain—around 0.1 kg a month—after stopping.
The Reason for the Rapid Rebound
Experts suggest the mode of action of the injections accounts for the heightened rebound.
These medications mimic a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production may cause the system to produce less of its own natural hormone, and may also lessen responsiveness to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this medication means hunger is uncontrolled, making binge eating far more likely."
An Ongoing Issue?
Health authorities recommend the injections for individuals with obesity-related medical conditions, accompanied by recommended lifestyle changes.
A number of clinicians contend that, due to the significant potential of relapse, the therapy might need to be ongoing.
This view is reinforced by pharmaceutical companies, who note that the results "emphasize the long-term nature of obesity," comparing it to managing conditions like high blood pressure.
Patient Accounts
Users who have come off the jabs describe a intense return of appetite.
"It was like a switch that goes on and you become extremely hungry," said one woman.
This challenge is exacerbated if individuals have not developed permanent lifestyle or habit changes during treatment.
Growing Adoption
Recent estimates suggest that a significant number of people in the UK have used weight-loss jabs in the past year, with interest continuing to grow.
- Adoption is more common among females than males.
- The 40s and 50s demographic shows the highest level of interest.
- Many obtain the drugs through private prescriptions rather than public health services.
Ultimately, clinicians caution that while the jabs are effective tools for shedding pounds, they are not a magic cure and long-term success likely depends on ongoing lifestyle support.
